Atmospheric Pressure Chemical Ionization Is a Suboptimal Ionization Source for Steroids
| Autor: | Steven J. Soldin, Jianghong Gu, Brian Stolze, Qian Sun |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty medicine.medical_treatment Clinical Biochemistry Urology Atmospheric-pressure chemical ionization Mass spectrometry Malignant disease Steroid 03 medical and health sciences 0302 clinical medicine Tandem Mass Spectrometry Ionization Adrenocortical Carcinoma medicine Humans Adrenocortical carcinoma business.industry Biochemistry (medical) medicine.disease Atmospheric Pressure 030104 developmental biology 030220 oncology & carcinogenesis Steroids business Chromatography Liquid Hormone |
| Zdroj: | Clinical Chemistry. 64:974-976 |
| ISSN: | 1530-8561 0009-9147 |
| Popis: | To the Editor: Biochemical measurement of steroid hormones is imperative for the diagnosis of adrenocortical carcinoma (ACC).1 The lack of clinical syndromes in over half of patients with ACC prevents the early diagnosis of this malignant disease if appropriate laboratory evaluations are not performed (1, 2). It is therefore with great interest that we read the recent study (1) by a research group at King's College. Their effort to apply a mass spectrometry-based steroid profiling assay to discriminate ACC from benign tumors is highly commendable. This new method has the potential to detect ACC at an early stage and thereby markedly improve the treatment and outcome of the patients. Although competitive immunoassays exhibit good precision (CVs generally |
| Databáze: | OpenAIRE |
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