Interplay between Mitophagy and Inflammasomes in Neurological Disorders
| Autor: | Dileep R. Yavagal, Kunjan R. Dave, Deepaneeta Sarmah, Veeresh Pabbala, Anupom Borah, Kiran Kalia, Harpreet Kaur, Geetesh Verma, Pallab Bhattacharya, Radhika Kesharwani, Leela Mounika, Vignesh Kotian |
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| Rok vydání: | 2019 |
| Předmět: |
Physiology
Inflammasomes Cognitive Neuroscience Biochemistry 03 medical and health sciences 0302 clinical medicine Mitophagy Cell integrity Autophagy Medicine Animals Humans 030304 developmental biology 0303 health sciences business.industry Neurodegeneration Brain Inflammasome Cell Biology General Medicine medicine.disease Mitochondria Crosstalk (biology) Nervous System Diseases business Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | ACS chemical neuroscience. 10(5) |
| ISSN: | 1948-7193 |
| Popis: | Mitophagy and inflammasomes have a pivotal role in the development of neuropathology. Molecular mechanisms behind mitophagy and inflammasomes are well-understood, but lacunae prevail in understanding the crosstalk between them in various neurological disorders. As mitochondrial dysfunction is the prime event in neurodegeneration, the clearance of impaired mitochondria is one of the main tasks for maintaining cell integrity in the majority of neuropathologies. Along with it, inflammasome activation also plays a major role, which is usually followed by mitochondrial dysfunction. The present review highlights basics of autophagy, mitophagy, and inflammasomes and the molecular mechanisms involved, and more importantly, it tries to elaborate the interplay between mitophagy and inflammasomes in various neurological disorders. This will help in upgrading the reader's understanding in exploring the link between mitophagy and inflammasomes, which has dealt with limitations in past studies. |
| Databáze: | OpenAIRE |
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