Effects of dizocilpine-induced glutamatergic blockade in the nucleus accumbens septi on the plus maze test
| Autor: | María P. Gargiulo De Aranda, Ángel José Martín Gargiulo, Manuel Alejandro Guevara, Augusto Pascual Ítalo Gargiulo, José Vicente Lafuente, Andres Acuña, Adriana Inés Landa de Gargiulo, Mercedes Maria Lucrecia Gargiulo, Gustavo Baiardi, Pascual Angel Gargiulo |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Time Factors CIENCIAS MÉDICAS Y DE LA SALUD Physiology medicine.medical_treatment Neurociencias Nucleus accumbens Receptors N-Methyl-D-Aspartate Nucleus Accumbens Rats Sprague-Dawley 03 medical and health sciences Glutamatergic 0302 clinical medicine Internal medicine Drug Discovery Male rats medicine Animals ANXIETY Maze Learning Saline Pharmacology Behavior Animal Dose-Response Relationship Drug business.industry DIZOCILPINE General Medicine Rats Blockade Dizocilpine Medicina Básica Endocrinology Anti-Anxiety Agents ACCUMBENS Disinhibition 030220 oncology & carcinogenesis PLUS MAZE RAT NMDA receptor Dizocilpine Maleate medicine.symptom business Excitatory Amino Acid Antagonists 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Journal of Basic and Clinical Physiology and Pharmacology. 29:241-246 |
| ISSN: | 2191-0286 0792-6855 |
| DOI: | 10.1515/jbcpp-2017-0100 |
| Popis: | In previous studies, we have observed that specific N-methyl-d-Aspartic acid (NMDA) antagonists and non-NMDA antagonists injected within the nucleus accumbens septi (NAS) induced an anxiolytic-like effect in the plus maze test in rats. In the present study, the effect of intracanalicular blockade of NMDA receptors using dizocilpine in the plus maze was studied in male rats bilaterally cannulated NAS. Rats were divided into five groups that received either 1 μL injections of saline or dizocilpine (MK-801, [5R,10S]-[+]-5-methyl-10,11-dihydro-5H-dibenzo [a,d] cyclohepten-5,10-imine) in different doses (0.5, 1, 2, or 4 μg) 15 min before testing. Time spent in the open arm increased under dizocilpine treatment with the two higher doses (2 and 4 μg, p |
| Databáze: | OpenAIRE |
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