An overview on in situ micronization technique – An emerging novel concept in advanced drug delivery
| Autor: | Y. Prasanna Raju, K.R. Vandana, V. Harini Chowdary, M. Sushma, N. Vijay Kumar |
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| Rok vydání: | 2014 |
| Předmět: |
Dissolution rate
Pharmacology Drug Materials science In-situ micronization media_common.quotation_subject Spray drying Pharmaceutical Science SCF Nanotechnology Particle size Review Supercritical fluid Dosage form Bioavailability Drug delivery Jet milling Micronization GeneralLiterature_REFERENCE(e.g. dictionaries encyclopedias glossaries) ComputingMilieux_MISCELLANEOUS media_common |
| Zdroj: | Saudi Pharmaceutical Journal. 22:283-289 |
| ISSN: | 1319-0164 |
| DOI: | 10.1016/j.jsps.2013.05.004 |
| Popis: | The use of drug powders containing micronized drug particles has been increasing in several pharmaceutical dosage forms to overcome the dissolution and bioavailability problems. Most of the newly developed drugs are poorly water soluble which limits dissolution rate and bioavailability. The dissolution rate can be enhanced by micronization of the drug particles. The properties of the micronized drug substance such as particle size, size distribution, shape, surface properties, and agglomeration behaviour and powder flow are affected by the type of micronization technique used. Mechanical communition, spray drying and supercritical fluid (SCF) technology are the most commonly employed techniques for production of micronized drug particles but the characteristics of the resulting drug product cannot be controlled using these techniques. Hence, a newer technique called in situ micronization is developed in order to overcome the limitations associated with the other techniques. This review summarizes the existing knowledge on in situ micronization techniques. The properties of the resulting drug substance obtained by in situ micronization were also compared. |
| Databáze: | OpenAIRE |
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