The kallikrein-kinin system in the colon and lung fluid from a cribriform degeneration (cri) mutant mouse
| Autor: | Laura Pullez, S. B. Vila, Omar H. Pivetta, O. L. Catanzaro, Adriana Zuccollo |
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| Rok vydání: | 1991 |
| Předmět: |
Male
endocrine system Pathology medicine.medical_specialty Cystic Fibrosis Ratón Colon Kallikrein-Kinin System Mutant Biology Cystic fibrosis General Biochemistry Genetics and Molecular Biology Mice medicine Animals Lysine Carboxypeptidase cardiovascular diseases General Pharmacology Toxicology and Pharmaceutics Glycoproteins chemistry.chemical_classification Lung urogenital system Respiratory disease General Medicine Kallikrein medicine.disease Molecular biology biological factors Mice Mutant Strains Disease Models Animal medicine.anatomical_structure Enzyme chemistry Kallikreins Glycoprotein Bronchoalveolar Lavage Fluid circulatory and respiratory physiology |
| Zdroj: | Life sciences. 48(25) |
| ISSN: | 0024-3205 |
| Popis: | The cribriform degeneration ( cri ) mutant mouse was widely studied in regard to the electrolyte and kallikrein metabolism because of its potentiality as a cystic fibrosis (CF) genetic animal model. In this paper the activity of the kallikrein-kinin system, and the kininase activity and glycoproteins concentration in colon and pulmonary lavage fluid (PLF) in homozygous mutant ( cri / cri ) and control sibling mice are described. The mutant mice showed a diminished kininogenase and kininase activity and glycoproteins concentrations in both studied organs. It is concluded that a kallikrein-kinin system alteration could be responsible of the cri / cri electrolyte defect. |
| Databáze: | OpenAIRE |
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