Cross-over data supporting long-term antibiotic treatment in patients with painful lower urinary tract symptoms, pyuria and negative urinalysis
| Autor: | Jennifer L. Rohn, Linda M. Collins, Sheela Swamy, Hristina Toteva, Tara Dehpour, Anthony Kupelian, Rajvinder Khasriya, James Malone-Lee, Dhanuson Dharmasena |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
pharmacy
Adult Male medicine.medical_specialty Urinalysis Urology Urinary system 030232 urology & nephrology Pain Urine 03 medical and health sciences Leukocyte Count Young Adult 0302 clinical medicine nursing Lower Urinary Tract Symptoms Lower urinary tract symptoms Recurrence Internal medicine medicine Humans Pyuria Aged Aged 80 and over 030219 obstetrics & reproductive medicine Cross-Over Studies medicine.diagnostic_test business.industry Obstetrics and Gynecology Interstitial cystitis health Middle Aged medicine.disease infection Anti-Bacterial Agents Nitrofurantoin Withholding Treatment Chronic Disease Retreatment Urinary Tract Infections Etiology Female medicine.symptom Symptom Assessment Off Treatment business |
| Zdroj: | International urogynecology journal. 30(3) |
| ISSN: | 1433-3023 0937-3462 |
| Popis: | To measure the effects of an unplanned, sudden cessation of treatment in an unselected group of patients with chronic painful LUTS managed with protracted antimicrobial treatment and to report these observational data collected from a cross-over process. The imposition of a guideline resulted in the immediate cessation of antibiotic treatment in a cohort of patients with chronic painful LUTS and microscopic pyuria. Patients were assessed before treatment withdrawal, whilst off treatment, and following reinstatement. Outcome measures included a validated symptom score, microscopic enumeration of urinary white cells and uroepithelial cells, and routine urine culture. These patients had reported treatment-resistant, painful LUTS for a mean of 6.5 years before treatment at this centre. Treatment was stopped in 221 patients (female = 210; male = 11; mean age = 56 years; SD = 17.81). Sixty-six per cent of women were post-menopausal. After unplanned treatment cessation, 199 patients (90%; female = 188; male = 9) reported deterioration. Eleven patients required hospital care in association with disease recurrence, including acute urinary tract infection (UTI) and urosepsis. Symptom scores increased after cessation and recovered on reinitiating treatment (F = 33; df = 2; p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink