Live-cell imaging reveals impaired detoxification of lipid-derived electrophiles is a hallmark of ferroptosis

Autor:	Ryan Karimi, Antonius T.M. Van Kessel, Gonzalo Cosa
Rok vydání:	2022
Předmět:	General Chemistry
Zdroj:	Chemical Science. 13:9727-9738
ISSN:	2041-6539 2041-6520
DOI:	10.1039/d2sc00525e
Popis:	The central mechanism in ferroptosis linking lipid hydroperoxide accumulation with cell death remains poorly understood. Although lipid hydroperoxides are known to break down to reactive lipid-derived electrophiles (LDEs), the ability of cells to detoxify increasing LDE levels during ferroptosis has not been studied. Here, we developed an assay (ElectrophileQ) correlating the cellular retention
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15beb813572a7b2fe2cfd221691a17e2 https://doi.org/10.1039/d2sc00525e Zobrazit plný text záznamu