Syngeneic and Xenogeneic Transplantations of Mesenchymal Stromal Cells Modify the Production of Reactive Oxygen Species by Blood Mononuclears of Mice
| Autor: | I. V. Semenkova, A. G. Konoplyannikov, E. V. Sayapina, V. N. Petrov, L. A. Lepekhina, O. E. Popovkina, E. V. Agaeva |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Transplantation Heterologous Mesenchymal Stem Cell Transplantation General Biochemistry Genetics and Molecular Biology Proinflammatory cytokine Mice 03 medical and health sciences 0302 clinical medicine In vivo medicine Animals Humans Transplantation Homologous Cells Cultured chemistry.chemical_classification Reactive oxygen species Chemistry Macrophages Mesenchymal stem cell Mesenchymal Stem Cells General Medicine Phenotype Transplantation 030104 developmental biology medicine.anatomical_structure Immunology Leukocytes Mononuclear Cancer research Bone marrow Reactive Oxygen Species Reprogramming 030217 neurology & neurosurgery |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 164:80-84 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | In vivo modifying effects of bone marrow mesenchymal stromal cells of humans and laboratory mice on ROS production by mouse blood mononuclears are studied by luminol-dependent zymosan-induced chemiluminescence after syngeneic and xenogeneic transplantation into systemic blood flow. The chemiluminescent activity of mouse blood mononuclears has increased early (1 day) after syngeneic (mouse mesenchymal stromal cells) and xenogeneic (human mesenchymal stromal cells) transplantation. Later, 7-21 days after syngeneic and xenogeneic transplantation, the chemiluminescent activity of mouse mononuclears is suppressed. The probable mechanisms of involvement of the transplanted mesenchymal stromal cells in reprogramming of the blood mononuclear phagocytes from proinflammatory (M1) to anti-inflammatory (M2) phenotype under conditions of their in vivo interactions are discussed; a frequent manifestation of this reprogramming is transition of the phase of activation into inhibition of ROS-producing activity of macrophages. |
| Databáze: | OpenAIRE |
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