Human monoclonal antibody fragment specific for glycoprotein G in herpes simplex virus type 2 with applications for serotype-specific diagnosis

Autor:	Francesca Bugli, Rosaria Santangelo, Rosalia Graffeo, Stefania Manzara, Paola Cattani, Riccardo Torelli, Giovanni Fadda
Rok vydání:	2004
Předmět:	Microbiology (medical) Serotype medicine.drug_class viruses Herpesvirus 2 Human Molecular Sequence Data Biology medicine.disease_cause Monoclonal antibody Herpesviridae Virus Immunoglobulin Fab Fragments Viral Envelope Proteins Alphaherpesvirinae Virology Chlorocebus aethiops medicine Animals Humans Amino Acid Sequence Vero Cells chemistry.chemical_classification Binding Sites Antibodies Monoclonal Herpes Simplex biology.organism_classification Molecular biology Subtyping Peptide Fragments Herpes simplex virus chemistry Glycoprotein
Zdroj:	Journal of clinical microbiology. 42(3)
ISSN:	0095-1137
Popis:	A combinatorial library was used to select a human monoclonal antibody fragment (Fab) with high affinity for G glycoprotein in herpes simplex virus type 2 (HSV-2). Tests with 112 clinical specimens demonstrated successful discrimination between HSV-2 and HSV-1, showing the potential of Fab as a low-cost tool for HSV subtyping in clinical diagnosis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15bbf5713f9fc737e228f307666f08a9 https://pubmed.ncbi.nlm.nih.gov/15004085 Zobrazit plný text záznamu