Increased expression of magnocellular arginine vasopressin mRNA in paraventricular nucleus of stress-induced depression-model rats
| Autor: | Isao Kitayama, Shinji Nakase, Kenji Hamanaka, Junichi Nomura, Hideaki Soya |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Vasopressin Arginine Corticotropin-Releasing Hormone Spontaneous recovery In situ hybridization General Biochemistry Genetics and Molecular Biology Adrenocorticotropic Hormone Stress Physiological Internal medicine Gene expression medicine Animals Chronic stress RNA Messenger General Pharmacology Toxicology and Pharmaceutics Rats Wistar Chemistry Depression General Medicine Rats Arginine Vasopressin Disease Models Animal Endocrinology medicine.anatomical_structure nervous system Hypothalamus Nucleus hormones hormone substitutes and hormone antagonists Paraventricular Hypothalamic Nucleus |
| Zdroj: | Life sciences. 63(1) |
| ISSN: | 0024-3205 |
| Popis: | Exposure of rats to long-term intermittent walking stress results in a persistent inactive behavior in the subsequent two weeks in about 50% of rats (depression-model rats) while the activity returns gradually toward baseline in other rats (spontaneous recovery rats). To explore the role of hypothalamic-pituitary-adrenal (HPA) axis in these depression-model rats, we examined changes in the gene expression of corticotropin-releasing factor (CRF) and arginine vasopressin (AVP) in the paraventricular nucleus (PVN) of the hypothalamus using in situ hybridization histochemistry. We imposed the intermittent walking stress for two weeks in male Wistar rats, then compared the response of the depression-model rats and spontaneous recovery rats. The expression of CRF mRNA in PVN increased significantly by 60% and 80% compared to controls, in the model and the recovery rats, respectively. The magnocellular AVP mRNA in PVN increased significantly in the model rats by 60% compared to controls. The concentration of plasma ACTH increased in the model rats, but no significant change in plasma corticosterone or AVP level was noted in all three groups. Our results suggest that increased magnocellular AVP in PVN plays an important role in the regulation of HPA axis of the depression-model rats induced by long-term walking stress. |
| Databáze: | OpenAIRE |
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