Microvessel density of hepatocellular carcinoma: its relationship with prognosis
Autor: | Zhao-You Tang, Hui-Chuan Sun, Yan-Nan Zhou, Bao-Rong Sun, Xiao-Ming Li, Zeng-Chen Ma |
---|---|
Rok vydání: | 1999 |
Předmět: |
Adult
Male Cancer Research Pathology medicine.medical_specialty HBsAg Cirrhosis Carcinoma Hepatocellular Angiogenesis Gastroenterology Disease-Free Survival Predictive Value of Tests Internal medicine medicine Humans Microvessel Pathological Retrospective Studies Hematology Neovascularization Pathologic business.industry Liver Neoplasms General Medicine Middle Aged medicine.disease Prognosis Immunohistochemistry Survival Analysis digestive system diseases Oncology Hepatocellular carcinoma cardiovascular system Female business |
Zdroj: | Journal of cancer research and clinical oncology. 125(7) |
ISSN: | 0171-5216 |
Popis: | Purpose: To elucidate the relationship between angiogenesis and prognosis after curative resection of hepatocellular carcinoma (HCC). Methods: An immunohistochemical study using anti-CD34 monoclonal antibody was carried out on surgical specimens from 78 HCC patients who had undergone curative resection; microvessel density (MVD) was counted and the overall survival and disease-free survival were analyzed retrospectively. Results: Blood vessels in the tumor were strongly stained by anti-CD34 antibody, but not those in the surrounding liver parenchyma. There were three types of tumor vessels: capillary-like (n = 59), sinusoid-like (n = 16) and mixed-type (n = 3). The median MVD count was 100 per field. The HCC were designated as hypovascular (n = 36) with an MVD count below 100, and hypervascular (n = 42) with an MVD count of 100 or more per field. The 5-year survival and disease-free survival rates were 49.7% and 42.8% respectively, and statistical analysis showed that the MVD level was not correlated with tumor size, capsule status, Edmondson's grade, α-fetoprotein level, associated cirrhosis, γ-glutamyltransferase, and serum HBsAg status. The sinusoid-like tumor vessels appeared more frequently in the more differentiated tumors (P |
Databáze: | OpenAIRE |
Externí odkaz: |