PINEOCYTOMA WITH NEURONAL DIFFERENTIATION DEMONSTRATED IMMUNOCYTOCHEMICALLY A Case Report
| Autor: | V. P. Collins |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Cytoplasm endocrine system Pathology medicine.medical_specialty medicine.drug_class Immunocytochemistry Enolase Synaptophysin Monoclonal antibody Immunoenzyme Techniques Pineal gland Intermediate Filament Proteins Immunology and Microbiology (miscellaneous) Neurofilament Proteins Glial Fibrillary Acidic Protein medicine Humans Neurons General Immunology and Microbiology Glial fibrillary acidic protein biology Brain Neoplasms Pineocytoma Membrane Proteins General Medicine medicine.disease Staining medicine.anatomical_structure nervous system Phosphopyruvate Hydratase biology.protein Pinealoma |
| Zdroj: | Acta Pathologica Microbiologica Scandinavica Series A :Pathology. :113-117 |
| ISSN: | 0108-0164 |
| Popis: | Stereotactic biopsies were obtained from a tumor in the pineal gland of a 37 year old man. Histological and smear preparations were studied using conventional staining techniques as well as immunocytochemical methods with monoclonal antibodies to glial fibrillary acidic protein (GFAP), the neurofilament proteins (NFP), the presynaptic vesicle protein synaptophysin as well as with antisera to neuronal specific enolase (NSE). The tumor was classified as a pineocytoma. The tumor cells uniformly contained no cytoplasmic GFAP but NFP, NSE and synaptophysin as shown by the immunocytochemical techniques. The pineocytoma could thus be subclassified as a pineocytoma with neuronal differentiation. The patient subsequently succumbed due to a hemorrhage into the tumor and autopsy confirmed the biopsy findings. We conclude that immunocytochemical techniques may prove invaluable in the subclassification of tumors of the pineal region. |
| Databáze: | OpenAIRE |
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