Comparison of four continuously administered progestogen plus oestradiol combinations for climacteric complaints
| Autor: | L. Å. Mattsson, T Sporrong, Göran Samsioe, Margareta Hellgren |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Adult
medicine.medical_specialty medicine.drug_class medicine.medical_treatment Physiology Endometrium Group B Random Allocation medicine Humans Aged Climacteric Gynecology Clinical Trials as Topic Estradiol Vasomotor Progestogen business.industry Megestrol Acetate Obstetrics and Gynecology General Medicine Megestrol Middle Aged medicine.disease Norethisterone acetate Menopause Norethindrone Acetate medicine.anatomical_structure Estrogen Megestrol acetate Drug Therapy Combination Female Norethindrone business Hormone medicine.drug |
| Zdroj: | BJOG: An International Journal of Obstetrics and Gynaecology. 95:1042-1048 |
| ISSN: | 1471-0528 1470-0328 |
| DOI: | 10.1111/j.1471-0528.1988.tb06511.x |
| Popis: | Summary. Sixty women with climacteric complaints who had not menstruated for at least 1 year were randomly allocated to receive one of four hormonal replacement regimens. All four formulations were administered daily and continuously and each contained 2 mg of micronized oestradiol-17β in combination with either norethisterone acetate 1 mg (group A) or 0·5 mg (group B) or megestrol acetate 5 mg (group C) or 2·5 mg (group D). The clinical efficacy was the same although the alleviation of vasomotor symptoms was somewhat slower in those women receiving preparation A. The endometrium was atrophied in nearly all biopsies. Irregular uterine bleeding was almost entirely confined to the earlier phase of the study and was substantially less with the formulation containing 1 mg norethisterone acetate. It is concluded that a continuous oestradiol-progestogen combination can be used for longterm treatment of climacteric complaints in postmenopausal women and that after 4 months the clinical efficacy is the same irrespective of the type and dose of progestogen administered. |
| Databáze: | OpenAIRE |
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