Cataract prevention in diabetic Octodon degus with Pfizer's sorbinil

Autor:	Manuel B. Datiles, Henry N. Fukui
Rok vydání:	1989
Předmět:	medicine.medical_specialty genetic structures Cataract formation Rodentia Gerbil Imidazolidines Cataract Streptozocin Diabetes Mellitus Experimental Cellular and Molecular Neuroscience chemistry.chemical_compound Cataracts Aldehyde Reductase Diabetes mellitus Internal medicine Lens Crystalline biology.domesticated_animal Medicine Animals Aldose reductase biology business.industry Imidazoles Aldose reductase activity medicine.disease eye diseases Sensory Systems Octodon degus Ophthalmology Disease Models Animal Endocrinology chemistry Sorbinil sense organs business Sugar Alcohol Dehydrogenases
Zdroj:	Current eye research. 8(3)
ISSN:	0271-3683
Popis:	The Octodon degus has been reported to have higher aldose reductase activity in the lens compared to the gerbil and rat. When made diabetic the degus develop cataracts within 4 weeks. We have been able to completely prevent cataract formation in diabetic degus using Pfizer's sorbinil for up to 6 months. This is further evidence of the role of aldose reductase in the formation of cataracts in diabetes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15b0a2f3b2be4d4b12217335c291d952 https://pubmed.ncbi.nlm.nih.gov/2523284 Zobrazit plný text záznamu