BLT1-mediated T cell trafficking is critical for rejection and obliterative bronchiolitis after lung transplantation
| Autor: | Benjamin D. Medoff, Andrew M. Tager, Andrew H. Lichtman, Gabriele S. V. Campanella, Sabina A. Islam, Edward Seung, John C. Wain, Seddon Y. Thomas, Leo C. Ginns, Andrew D. Luster, Terry K. Means, Nir Grabie |
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| Rok vydání: | 2005 |
| Předmět: |
Graft Rejection
Ovalbumin T cell medicine.medical_treatment Immunology Receptors Leukotriene B4 Bronchiolitis obliterans Mice Transgenic CD8-Positive T-Lymphocytes Biology Article Effector T-Lymphocyte Mice 03 medical and health sciences 0302 clinical medicine medicine Animals Humans Immunology and Allergy Lung transplantation Bronchiolitis Obliterans 030304 developmental biology Mice Knockout Mice Inbred BALB C 0303 health sciences Lung Base Sequence T lymphocyte respiratory system medicine.disease respiratory tract diseases 3. Good health Mice Inbred C57BL Trachea Transplantation Disease Models Animal medicine.anatomical_structure Collagen CD8 Lung Transplantation 030215 immunology |
| Zdroj: | The Journal of Experimental Medicine |
| ISSN: | 1540-9538 0022-1007 |
| Popis: | Leukotriene B4 is a lipid mediator that recently has been shown to have potent chemotactic activity for effector T lymphocytes mediated through its receptor, BLT1. Here, we developed a novel murine model of acute lung rejection to demonstrate that BLT1 controls effector CD8+ T cell trafficking into the lung and that disruption of BLT1 signaling in CD8+ T cells reduces lung inflammation and mortality in the model. In addition, we used BLT1-deficient mice and a BLT1 antagonist in two tracheal transplant models of lung transplantation to demonstrate the importance of BLT1 for the recruitment of T cells into tracheal allografts. We also show that BLT1-mediated CD8+ T cell recruitment plays an important role in the development of airway fibroproliferation and obliteration. Finally, in human studies of lung transplant recipients, we found that BLT1 is up-regulated on T lymphocytes isolated from the airways of patients with obliterative bronchiolitis. These data demonstrate that BLT1 contributes to the development of lung rejection and obliterative bronchiolitis by mediating effector T lymphocyte trafficking into the lung. This is the first report that describes a pathologic role for BLT1-mediated T lymphocyte recruitment in disease and identifies BLT1 as a potential therapeutic target after lung transplantation. |
| Databáze: | OpenAIRE |
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