Stimulation of the left dorsolateral prefrontal cortex with slow rTMS enhances verbal memory formation

Autor: Simon Hanslmayr, Benjamin Johannes Stauch, Verena Braun, Mircea van der Plas
Rok vydání: 2021
Předmět:
Male
Physiology
medicine.medical_treatment
Stimulation
Electroencephalography
Cognition
Learning and Memory
Mathematical and Statistical Techniques
0302 clinical medicine
Medicine and Health Sciences
Biology (General)
Prefrontal cortex
Episodic memory
Clinical Neurophysiology
Brain Mapping
0303 health sciences
medicine.diagnostic_test
General Neuroscience
Statistics
Brain
Metaanalysis
Transcranial Magnetic Stimulation
Electrophysiology
Bioassays and Physiological Analysis
Memory
Short-Term
Brain Electrophysiology
Physical Sciences
Memory Recall
Female
Anatomy
General Agricultural and Biological Sciences
psychological phenomena and processes
Research Article
Adult
Imaging Techniques
QH301-705.5
Neurophysiology
Prefrontal Cortex
Neuroimaging
Surgical and Invasive Medical Procedures
Biology
Research and Analysis Methods
behavioral disciplines and activities
General Biochemistry
Genetics and Molecular Biology
03 medical and health sciences
Memory
mental disorders
medicine
Functional electrical stimulation
Humans
Statistical Methods
Transcranial Stimulation
030304 developmental biology
Analysis of Variance
Functional Electrical Stimulation
General Immunology and Microbiology
Recall
Electrophysiological Techniques
Biology and Life Sciences
Correction
Transcranial magnetic stimulation
nervous system
Cognitive Science
Clinical Medicine
Verbal memory
Neuroscience
Mathematics
030217 neurology & neurosurgery
Zdroj: PLoS Biology
PLoS Biology, Vol 19, Iss 9, p e3001363 (2021)
ISSN: 1545-7885
1544-9173
Popis: Encoding of episodic memories relies on stimulus-specific information processing and involves the left prefrontal cortex. We here present an incidental finding from a simultaneous EEG-TMS experiment as well as a replication of this unexpected effect. Our results reveal that stimulating the left dorsolateral prefrontal cortex (DLPFC) with slow repetitive transcranial magnetic stimulation (rTMS) leads to enhanced word memory performance. A total of 40 healthy human participants engaged in a list learning paradigm. Half of the participants (N = 20) received 1 Hz rTMS to the left DLPFC, while the other half (N = 20) received 1 Hz rTMS to the vertex and served as a control group. Participants receiving left DLPFC stimulation demonstrated enhanced memory performance compared to the control group. This effect was replicated in a within-subjects experiment where 24 participants received 1 Hz rTMS to the left DLPFC and vertex. In this second experiment, DLPFC stimulation also induced better memory performance compared to vertex stimulation. In addition to these behavioural effects, we found that 1 Hz rTMS to DLPFC induced stronger beta power modulation in posterior areas, a state that is known to be beneficial for memory encoding. Further analysis indicated that beta modulations did not have an oscillatory origin. Instead, the observed beta modulations were a result of a spectral tilt, suggesting inhibition of these parietal regions. These results show that applying 1 Hz rTMS to DLPFC, an area involved in episodic memory formation, improves memory performance via modulating neural activity in parietal regions.
Encoding of episodic memories relies on stimulus-specific information processing and involves the left prefrontal cortex. An incidental finding from a simultaneous EEG-TMS experiment reveals that applying 1-Hz repetitive transcranial magnetic stimulation to this area of the brain improves memory performance by modulating neural activity in parietal regions.
Databáze: OpenAIRE
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