Microalbuminuria and mortality in long-duration type 1 diabetes
| Autor: | Kate V. Allen, James D. Walker |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Predictive Value of Tests Risk Factors Diabetes mellitus Internal medicine Epidemiology Internal Medicine medicine Albuminuria Humans Diabetic Nephropathies Risk factor Aged Advanced and Specialized Nursing Aged 80 and over Type 1 diabetes Proteinuria business.industry Middle Aged medicine.disease Prognosis Surgery Diabetes Mellitus Type 1 Cohort Kidney Failure Chronic Microalbuminuria Female medicine.symptom Complication business Follow-Up Studies |
| Zdroj: | Diabetes care. 26(8) |
| ISSN: | 0149-5992 |
| Popis: | OBJECTIVE—Microalbuminuria is a recognized risk factor for increased mortality and renal failure in type 1 diabetes. Whether it remains a powerful predictor in patients with a long duration of type 1 diabetes is not known. We ascertained the prognostic significance of abnormal urinary albumin excretion in a cohort of patients with at least 30 years of type 1 diabetes. RESEARCH DESIGN AND METHODS—A total of 190 patients with a disease duration of type 1 diabetes of at least 30 years with baseline and 5 years of follow-up. RESULTS—At baseline 66% were normoalbuminuric, and at 5 years 11% of this cohort had died. Of the 22% who were microalbuminuric at baseline, 26% had died, and of the 8% with persistent proteinuria at baseline, 44% had died. Of the 4% with end-stage renal failure at baseline, 71% had died within 5 years. Death was attributable to a cardiovascular cause in two-thirds of the cases in all groups. CONCLUSIONS—Even in those with a long duration of type 1 diabetes, the presence of abnormal urinary excretion remains a powerful predictor of increased mortality. |
| Databáze: | OpenAIRE |
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