Rheumatologic disorders in patients undergoing esophageal manometry: prevalence, symptom characteristics, and manometric findings
| Autor: | Zubair Malik, Anam Qureshi, Henry P. Parkman, Asad Jehangir |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Manometry Nausea Gastroenterology Arthritis Rheumatoid Hiatal hernia 03 medical and health sciences 0302 clinical medicine Internal medicine Prevalence medicine Humans Esophageal Motility Disorders Esophagus 030203 arthritis & rheumatology business.industry Heartburn General Medicine Middle Aged medicine.disease Dysphagia medicine.anatomical_structure Esophageal motility disorder Rheumatoid arthritis Female 030211 gastroenterology & hepatology medicine.symptom Bolus (digestion) business |
| Zdroj: | Diseases of the Esophagus. 34 |
| ISSN: | 1442-2050 1120-8694 |
| Popis: | Summary Rheumatologic disorders (RDs) can have gastrointestinal (GI) manifestations. Systemic sclerosis (SSc) patients often have upper GI symptoms from absent esophageal contractility (AC). Upper GI symptom characteristics and high-resolution esophageal manometry with impedance (HREMI) findings of other RDs have not been well studied. We aimed to: (i) determine the prevalence of RD in patients undergoing HREMI and (ii) assess the symptom characteristics and manometric findings of these patients. Patients undergoing HREMI (July 2018 to March 2020) rated their GI symptoms’ severity. Healthy volunteers (HVs) also underwent HREMI. Of the 1,003 patients, 90 (9%) had RD (mean age: 55.3 ± 1.4 years, 73.3% females), most commonly SSc (n = 27), rheumatoid arthritis (RA, n = 20), and systemic lupus erythematosus (SLE, n = 11). The most severe upper GI symptoms in patients with RD were heartburn, regurgitation, nausea, and dysphagia, with no significant differences in their severities between SSc, RA, and SLE. RD patients had higher upper esophageal sphincter (UES) pressures, lower distal contractile integral (DCI), lower bolus clearance, and more frequent hiatal hernia (HH) on HREMI (all P |
| Databáze: | OpenAIRE |
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