Intake of marine n-3 polyunsaturated fatty acids and the risk of incident peripheral artery disease
| Autor: | Erik Berg Schmidt, Christian Sørensen Bork, Anne N. Lasota, Stine Krogh Venø, Kim Overvad, Linda Tram, Søren Lundbye-Christensen |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Arterial disease Medicine (miscellaneous) Physiology 030209 endocrinology & metabolism Disease Lower risk 03 medical and health sciences 0302 clinical medicine FISH Medicine VALIDITY FOOD FREQUENCY QUESTIONNAIRE chemistry.chemical_classification 030109 nutrition & dietetics Nutrition and Dietetics Proportional hazards model business.industry food and beverages CANCER Eicosapentaenoic acid chemistry Docosahexaenoic acid Cohort lipids (amino acids peptides and proteins) business OMEGA-3-FATTY-ACIDS Polyunsaturated fatty acid |
| Zdroj: | Tram, L, Bork, C S, Venø, S K, Lasota, A N, Lundbye-Christensen, S, Schmidt, E B & Overvad, K 2021, ' Intake of marine n-3 polyunsaturated fatty acids and the risk of incident peripheral artery disease ', European Journal of Clinical Nutrition, vol. 75, no. 10, pp. 1483-1490 . https://doi.org/10.1038/s41430-021-00858-w |
| Popis: | BACKGROUND: A high intake of marine n-3 polyunsaturated fatty acids (PUFAs) may lower the risk of coronary heart disease and ischemic stroke. The association between intake of marine n-3 PUFAs and development of peripheral artery disease (PAD), however, remains unexplored. We hypothesised that intake of marine n-3 PUFAs, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and the sum of EPA + DHA was associated with a lower risk of incident PAD.METHODS: We used data from the Danish Diet, Cancer and Health cohort and investigated the associations between intake of EPA, DHA and EPA + DHA and development of PAD. Information on intake of n-3 PUFAs was obtained through a validated food frequency questionnaire. Potential PAD cases were identified through linkage to the Danish National Patient Register and subsequently, all cases were validated.RESULTS: Data were available from 55,248 participants and during a median of 13.6 years of follow-up, 950 cases of PAD were identified. Multivariate Cox regression analyses with adjustments for established risk factors showed no statistically significant associations between intake of EPA (p = 0.255), DHA (p = 0.071) or EPA + DHA (p = 0.168) and the rate of incident PAD.CONCLUSIONS: We did not confirm our hypothesis that intake of EPA, DHA or EPA + DHA was associated with a lower risk of incident PAD. |
| Databáze: | OpenAIRE |
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