Copper Metabolism in Iron-Deficient Maternal and Neonatal Rats
| Autor: | Peggy Elizabeth Moran, Adria Rothman Sherman |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
medicine.medical_specialty
Amniotic fluid Medicine (miscellaneous) chemistry.chemical_element Biology Absorption Fetus Pregnancy Internal medicine Placenta Lactation medicine Animals Maternal-Fetal Exchange reproductive and urinary physiology Anemia Hypochromic Nutrition and Dietetics Rats Inbred Strains Iron Deficiencies Metabolism Iron deficiency Amniotic Fluid medicine.disease Copper Animals Suckling Rats medicine.anatomical_structure Endocrinology Liver chemistry Iron-deficiency anemia Female Spleen Subcellular Fractions |
| Zdroj: | The Journal of Nutrition. 114:298-306 |
| ISSN: | 0022-3166 |
| Popis: | Groups of rats were fed diets providing 8 ppm iron (-Fe) and 250 ppm iron (+Fe) throughout pregnancy and lactation. In spite of the increase in apparent absorption of iron in pregnant -Fe dams, iron deficiency anemia developed, resulting in decreased iron levels in placenta, amniotic fluid and fetal liver. Copper concentration of amniotic fluid was elevated in -Fe dams. On day 17 of lactation, -Fe dams and their suckling pups had hematologic evidence of iron deficiency. While liver and spleen iron decreased in 17-day-old pups, levels of copper increased. Subcellularly, the greatest increase in hepatic copper in -Fe pups was found in the cytosol, thus the increased copper deposition is not similar to copper loading. Serum ceruloplasmin activity was significantly elevated in -Fe lactating dams and was slightly, but not significantly, increased in -Fe pregnant dams and suckling pups. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|