Genome-wide meta-analysis associates GPSM1 with type 2 diabetes, a plausible gene involved in skeletal muscle function
| Autor: | Esteban J. Parra, E-Shyong Tai, Habiba Alsafar, Enrico Petretto, Jirong Long, Amelia Li Min Tan, Xueling Sim, Yik Ying Teo, Miguel Cruz, Huimei Chen, Qiuju Ding |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Locus (genetics) Single-nucleotide polymorphism 030105 genetics & heredity Biology Polymorphism Single Nucleotide Diabetes Mellitus Experimental Mice 03 medical and health sciences Asian People Genetics medicine Animals Humans Genetic Predisposition to Disease Allele Muscle Skeletal Gene Genetics (clinical) Guanine Nucleotide Dissociation Inhibitors Genetic association Skeletal muscle 030104 developmental biology medicine.anatomical_structure Diabetes Mellitus Type 2 CTCF Expression quantitative trait loci Genome-Wide Association Study |
| Zdroj: | Journal of Human Genetics. 65:411-420 |
| ISSN: | 1435-232X 1434-5161 2853-9249 |
| Popis: | Genome-wide association studies (GWASs) have identified many genetic variations associated with type 2 diabetes mellitus (T2DM) in Asians, but understanding the functional genetic variants that influence traits is often a complex process. In this study, fine mapping and other analytical strategies were performed to investigate the effects of G protein signaling modulator 1 (GPSM1) on insulin resistance in skeletal muscle. A total of 128 single-nucleotide polymorphisms (SNPs) within GPSM1 were analysed in 21,897 T2DM cases and 32,710 healthy controls from seven GWASs. The SNP rs28539249 in intron 9 of GPSM1 showed a nominally significant association with T2DM in Asians (OR = 1.07, 95% CI = 1.04–1.10, P |
| Databáze: | OpenAIRE |
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