Development of chronic lymphocytic leukaemia in a patient with polycythaemia vera
Autor: | Emmanuel Nikiforakis, Demetra Aanagnostou-Keramida, Antonios G. Papayannis |
---|---|
Rok vydání: | 1982 |
Předmět: |
Male
Polycythaemia Pathology medicine.medical_specialty T-Lymphocytes Leukocyte Count Mice Fibrosis Bone Marrow hemic and lymphatic diseases medicine Animals Humans Lymphocytes Polycythemia Vera Aged B-Lymphocytes medicine.diagnostic_test business.industry Cell Differentiation Hematology Phlebotomy medicine.disease Hematopoietic Stem Cells Leukemia Lymphoid Leukemia medicine.anatomical_structure Erythrocyte sedimentation rate Bone marrow business Abnormal Lymphocyte Busulfan medicine.drug |
Zdroj: | Scandinavian journal of haematology. 29(1) |
ISSN: | 0036-553X |
Popis: | A 73-year-old patient who had polycythaemia vera (PV), and who 6 years later developed chronic lymphocytic leukaemia (CCL) is described. 2 years after the appearance of CLL, the polycythaemic phase showed a remission following treatment with phlebotomy and busulfan. CLL did not make all the characteristics of PV disappear: leucocyte alkaline phosphatase and fibrosis of the bone marrow remained increased and the erythrocyte sedimentation rate remained low. The abnormal lymphocytes were B-cells and had the peculiarity that most of their nuclei showed a deep cleft, and some were bilobed. Chromosomal studies of the bone marrow showed the presence of a metacentric chromosome in the C-group, while the karyotype of the peripheral blood was normal. This case is described because of the rarity of the coexistence of these 2 diseases in the same patient. |
Databáze: | OpenAIRE |
Externí odkaz: |
Pro tento záznam nejsou dostupné žádné jednotky.