Local dose–effect relations for lung perfusion post stereotactic body radiotherapy
| Autor: | José Belderbos, Jan-Jakob Sonke, Joos V. Lebesque, Maddalena Rossi, A. Scheenstra, Eugène M.F. Damen |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Lung Neoplasms Radiosurgery Logistic regression Humans Medicine Dose effect Radiology Nuclear Medicine and imaging In patient Lung cancer Lung Aged Aged 80 and over Tomography Emission-Computed Single-Photon business.industry Radiotherapy Planning Computer-Assisted Lung perfusion Hematology Middle Aged medicine.disease Peripheral Logistic Models Oncology Female Tomography X-Ray Computed business Nuclear medicine Stereotactic body radiotherapy Perfusion |
| Zdroj: | Radiotherapy and Oncology. 107:398-402 |
| ISSN: | 0167-8140 |
| DOI: | 10.1016/j.radonc.2013.04.003 |
| Popis: | To model the local dose-effect relation for lung perfusion reduction in lung cancer patients treated with stereotactic body radiotherapy (SBRT).Forty-two patients having upper-lobe peripheral tumours5 cm treated with SBRT (3×18 Gy) underwent single-photon emission computed-tomography (SPECT) scans to measure the lung perfusion 2 weeks pre-SBRT, 4-months post-SBRT, and for 8 patients 15-months post-SBRT. The relation between the calculated relative local perfusion reduction and the normalised total dose (α/β=3 Gy) at 4-months post-SBRT was modeled by 3-parameter logistic model and 2-parameter linear-maximum model.The relation between local dose and perfusion reduction at 4-months post-SBRT showed a maximum effect of 42.6% at doses100 Gy and was best described by the logistic model with parameters (95% CI): M=42.6% (40.7-44.6), D50=28.7 Gy (26.3-31.1) and k=2.2 (1.8-2.5). A significant increase of this maximum effect to 65.2% was found at 15-months post-SBRT.The relation between local dose and perfusion reduction in patients treated with SBRT can be modeled by a 3-parameter logistic model. This demonstrated relationship 4-months post-SBRT approaches a plateau for doses100 Gy, where 90% of the maximum lung-perfusion reduction is observed at NTD=78 Gy. A further perfusion reduction compared to 4-months post-SBRT was observed fifteen months post-SBRT. |
| Databáze: | OpenAIRE |
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