| Autor: |
Mostafa Elmansy, Jasper M. Morrow, Sachit Shah, Arne Fischmann, Stephen Wastling, Mary M. Reilly, Michael G. Hanna, Eman Mohamed Helmy, Saleh Saleh El‐Essawy, John S. Thornton, Tarek A. Yousry |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
MusclenerveREFERENCES. 66(6) |
| ISSN: |
1097-4598 |
| Popis: |
Inclusion body myositis (IBM) is a myopathic condition but in some patients has been associated with an axonal length-dependent polyneuropathy. In this study, we quantified the cross-sectional area of the sciatic and tibial nerves in patients with IBM comparing with Charcot-Marie-Tooth disease type 1A (CMT1A) and healthy controls using magnetic resonance neurography (MRN).MRN of the sciatic and tibial nerves was performed at 3T using MPRAGE and Dixon acquisitions. Nerve cross-sectional area (CSA) was measured at the mid-thigh and upper third calf regions by an observer blinded to the diagnosis. Correlations were performed between these measurements and clinical data.A total of 20 patients with IBM, 20 CMT1A and 29 healthy controls (age- and sex-matched) were studied. Sciatic nerve CSA was significantly enlarged in patients with IBM and CMT1A compared to controls (sciatic nerve mean CSA 62.3 ± 22.9 mmMRN reveals significant hypertrophy of the sciatic and tibial nerves in patients with IBM and CMT1A compared to controls. Further studies are needed to correlate with neurophysiological measures and assess whether this finding is useful diagnostically. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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