Pseudorabies virus-induced suppression of major histocompatibility complex class I antigen expression
| Autor: | Patricia C. O'Brien, M. W. Mellencamp, J. R. Stevenson |
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| Rok vydání: | 1991 |
| Předmět: |
Transcription
Genetic Rabies viruses Immunology Down-Regulation Pseudorabies Transferrin receptor medicine.disease_cause Major histocompatibility complex Microbiology Herpesviridae Virus Immune tolerance Antigen Virology Alphaherpesvirinae Receptors Transferrin Immune Tolerance medicine Animals biology Histocompatibility Antigens Class I biology.organism_classification Herpesvirus 1 Suid Molecular biology Insect Science biology.protein Research Article |
| Zdroj: | Journal of Virology. 65:3365-3368 |
| ISSN: | 1098-5514 0022-538X |
| DOI: | 10.1128/jvi.65.6.3365-3368.1991 |
| Popis: | The ability of pseudorabies virus (PrV) to down-modulate expression of major histocompatibility complex class I antigens in murine and porcine cells was investigated. When quantified by flow cytometry, surface expression of class I Kk and Dk antigens on PrV-infected cells decreased by 60% or more. Down-modulation was associated with a decrease in total cellular class I antigens, indicating regulation at the transcriptional or posttranscriptional level. PrV did not suppress expression of transferrin receptor, suggesting a selective regulatory mechanism. |
| Databáze: | OpenAIRE |
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