Hormonal pleiotropy and the juvenile hormone regulation ofDrosophila development and life history
| Autor: | Marc Tatar, Meng-Ping Tu, Thomas Flatt |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Aging
Cell signaling media_common.quotation_subject Diapause General Biochemistry Genetics and Molecular Biology Pleiotropy Animals Insulin Metamorphosis Drosophila Organism media_common Genetics Behavior Animal biology Reproduction Metamorphosis Biological biology.organism_classification Biological Evolution Neurosecretory Systems Hormones Juvenile Hormones Drosophila melanogaster Phenotype Evolutionary biology Juvenile hormone Signal Transduction |
| Zdroj: | BioEssays. 27:999-1010 |
| ISSN: | 1521-1878 0265-9247 |
| DOI: | 10.1002/bies.20290 |
| Popis: | Summary Understandinghowtraitsareintegratedattheorganismal level remains a fundamental problem at the interface of developmental and evolutionary biology. Hormones, regulatory signaling molecules that coordinate multiple developmental and physiological processes, are major determinants underlying phenotypic integration. The probably best example for this is the lipid-like juvenile hormone (JH) in insects. Here we review the manifold effects of JH, the most versatile animal hormone, with an emphasis on the fruit fly Drosophila melanogaster ,a n organism amenable to both genetics and endocrinology. JH affects a remarkable number of processes and traits in Drosophila development and life history, including metamorphosis, behavior, reproduction, diapause, stress resistance and aging. While many molecular details underlying JH signaling remain unknown, we argue that studying ‘‘hormonal pleiotropy’’ offers intriguing insights into phenotypic integration and the mechanisms underlying life history evolution. In particular, we illustrate the role of JH as a key mediator of life history trade-offs. BioEssays 27:999–1010, 2005. 2005 Wiley Periodicals, Inc. |
| Databáze: | OpenAIRE |
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