Gentamicin synergises with azoles against drug-resistant Candida albicans
| Autor: | Lei Yuan, Shi Jinyi, Mengjiao Lu, Shujuan Sun, Cuixiang Yu, Cui Xueyan |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Antifungal Agents medicine.drug_class 030106 microbiology Antibiotics Drug resistance Microbial Sensitivity Tests Biology Pharmacology Moths Microbiology 03 medical and health sciences Drug Resistance Fungal Candida albicans medicine Animals Humans Pharmacology (medical) Fluconazole Cross Infection Aminoglycoside Membrane Transport Proteins Drug Synergism General Medicine biology.organism_classification Corpus albicans Infectious Diseases Phospholipases Biofilms Larva Gentamicin Efflux Gentamicins medicine.drug |
| Zdroj: | International journal of antimicrobial agents. 51(1) |
| ISSN: | 1872-7913 |
| Popis: | Candida spp. are the primary opportunistic pathogens of nosocomial fungal infections, causing both superficial and life-threatening systemic infections. Combination therapy for fungal infections has attracted considerable attention, especially for those caused by drug-resistant fungi. Gentamicin (GM), an aminoglycoside antibiotic, has weak antifungal activity against Fusarium spp. The aim of this study was to investigate the interactions of GM with azoles against Candida spp. and the underlying mechanisms. In a chequerboard assay, GM was found not only to work synergistically with azoles against planktonic cells of drug-resistant Candida albicans with a fractional inhibitory concentration index (FICI) of 0.13-0.14, but also synergised with fluconazole (FLC) against C. albicans biofilms pre-formed in |
| Databáze: | OpenAIRE |
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