Essential Thrombocythemia Following Immune thrombocytopenia With JAK2 V617F Mutation: A Case Report

Autor:	Kimiya Dadashizadeh, Mehrdad Payandeh, Saba Yari, Mehrnoush Aeinfar
Rok vydání:	2021
Předmět:	Jak2 mutation Essential thrombocythemia business.industry Ocean Engineering medicine.disease Immune thrombocytopenia immune system diseases hemic and lymphatic diseases Immunology Mutation (genetic algorithm) medicine Medicine business JAK2 V617F
Zdroj:	Case Reports in Clinical Practice, Vol 6, Iss 4 (2021)
ISSN:	2538-2691 2538-2683
DOI:	10.18502/crcp.v6i4.7853
Popis:	Immune Thrombocytopenia (ITP) is an autoimmune bleeding disorder. Tyrosine Kinase JAK2 (JAK2 V617F) mutation occurs in nearly 60% of Essential Thrombocythemia (ET) patients. Both diseases produce impaired platelet. We describe a case with ET following ITP. So far, only 3 reports described ET following ITP. We report the fourth patient with JAK2 V617F mutation at the onset of ITP presented 20 years ago that needed splenectomy. The association of these two diseases may recommend similar pathogenic mechanisms between Myeloproliferative Neoplasms (MPNs) and ITP that should be further explored.
Databáze:	OpenAIRE
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