The influence of rat strain on the development of neuropathic pain and comorbid anxio-depressive behaviour after nerve injury
| Autor: | Klas S P Abelson, Sara Hestehave, Daniel R. Andersson, Tina Brønnum Pedersen, David P. Finn, Gordon Munro |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Elevated plus maze SNi medicine.drug_class Chronic pain Stimulation Comorbidity Anxiety Article Feces 03 medical and health sciences 0302 clinical medicine Inbred strain Opioid receptor Internal medicine Genetic predisposition Animals Medicine Nerve Tissue Gait Multidisciplinary Behavior Animal Depression business.industry Rats Inbred Strains Organ Size Nerve injury 030104 developmental biology Endocrinology Hyperalgesia Receptors Opioid Neuropathic pain Neuralgia medicine.symptom Corticosterone business 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports Hestehave, S, Abelson, K S P, Brønnum Pedersen, T, Finn, D P, Andersson, D R & Munro, G 2020, ' The influence of rat strain on the development of neuropathic pain and comorbid anxio-depressive behaviour after nerve injury ', Scientific Reports, vol. 10, no. 1, 20981 . https://doi.org/10.1038/s41598-020-77640-8 |
| ISSN: | 2045-2322 |
| Popis: | Back-translating the clinical manifestations of human disease burden into animal models is increasingly recognized as an important facet of preclinical drug discovery. We hypothesized that inbred rat strains possessing stress hyper-reactive-, depressive- or anxiety-like phenotypes may possess more translational value than common outbred strains for modeling neuropathic pain. Rats (inbred: LEW, WKY, F344/ICO and F344/DU, outbred: Crl:SD) were exposed to Spared Nerve Injury (SNI) and evaluated routinely for 6 months on behaviours related to pain (von Frey stimulation and CatWalk-gait analysis), anxiety (elevated plus maze, EPM) and depression (sucrose preference test, SPT). Markers of stress reactivity together with spinal/brain opioid receptor expression were also measured. All strains variously developed mechanical allodynia after SNI with the exception of stress-hyporesponsive LEW rats, despite all strains displaying similar functional gait-deficits after injury. However, affective changes reflective of anxiety- and depressive-like behaviour were only observed for F344/DU in the EPM, and for Crl:SD in SPT. Although differences in stress reactivity and opioid receptor expression occurred, overall they were relatively unaffected by SNI. Thus, anxio-depressive behaviours did not develop in all strains after nerve injury, and correlated only modestly with degree of pain sensitivity or with genetic predisposition to stress and/or affective disturbances. |
| Databáze: | OpenAIRE |
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