Functional Genomics for Cancer Drug Target Discovery
| Autor: | Benjamin Haley, Filip Roudnicky |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Gene Editing
0301 basic medicine Cancer Research Genome Human Cancer drugs Drug target Antineoplastic Agents Genomics Computational biology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Oncology Genome editing Neoplasms 030220 oncology & carcinogenesis Complementarity (molecular biology) Drug Discovery Animals Humans CRISPR Genetic Testing CRISPR-Cas Systems Functional genomics Genetic screen |
| Zdroj: | Cancer Cell. 38:31-43 |
| ISSN: | 1535-6108 |
| DOI: | 10.1016/j.ccell.2020.04.006 |
| Popis: | Functional genomics describes a field of biology that uses a range of approaches for assessing gene function with high-throughput molecular, genetic, and cellular technologies. The near limitless potential for applying these concepts to study the activities of all genetic loci has completely upended how today's cancer biologists tackle drug target discovery. We provide an overview of contemporary functional genomics platforms, highlighting areas of distinction and complementarity across technologies, so as to aid in the development or interpretation of cancer-focused screening efforts. |
| Databáze: | OpenAIRE |
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