Mutator plasmid in a nalidixic acid-resistant strain of Shigella dysenteriae type 1
| Autor: | R. J. Pinney, Y. J. Drabu, P. H. Blakemore, J. E. Ambler |
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| Rok vydání: | 1993 |
| Předmět: |
Microbiology (medical)
Shigella dysenteriae Nalidixic acid DNA Repair Ultraviolet Rays Biology Microbiology Nalidixic Acid Plasmid medicine Escherichia coli Pharmacology (medical) Antibacterial agent Pharmacology Strain (chemistry) Drug Resistance Microbial biology.organism_classification Enterobacteriaceae Virology Infectious Diseases Conjugation Genetic Mutation Trimethoprim Resistance Bacteria medicine.drug Plasmids |
| Zdroj: | The Journal of antimicrobial chemotherapy. 31(6) |
| ISSN: | 0305-7453 |
| Popis: | A clinical isolate of Shigella dysenteriae from Kashmir, resistant to seven antibacterial agents including nalidixic acid, carried four plasmids, only one of which was transferable by conjugation. This plasmid, designated pYD1, conferred trimethoprim resistance and increased the frequency of mutation to nalidixic acid resistance in recipient strains. Thus, although nalidixic acid resistance was not carried on a transferable plasmid, the presence of pYD1 increased the frequency at which the strain mutated to nalidixic acid resistance. |
| Databáze: | OpenAIRE |
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