Differences in the effects of BMI on bone microstructure between loaded and unloaded bones assessed by HR-pQCT in Japanese postmenopausal women
Autor: | Junya Ozawa, Miyuki Mori, Nobukazu Okimoto, Manabu Tsukamoto, Ryoichi Nakamura, Makoto Kawasaki, Nobuhiro Kito, Yoshiaki Ikejiri, Norifumi Fujii, Saeko Fujiwara, Toru Yoshioka, Shogo Takano |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
musculoskeletal diseases
Osteoporosis Diseases of the musculoskeletal system medicine Bone mineral density Tibia Quantitative computed tomography Body mass index Bone mineral Orthodontics Postmenopausal women medicine.diagnostic_test business.industry General Medicine General Chemistry Microstructure medicine.disease musculoskeletal system High-resolution peripheral quantitative computed tomography medicine.anatomical_structure RC925-935 Loaded bone Cortical bone Original Article business |
Zdroj: | Osteoporosis and Sarcopenia Osteoporosis and Sarcopenia, Vol 7, Iss 2, Pp 54-62 (2021) |
ISSN: | 2405-5263 2405-5255 |
Popis: | Objectives The relationship between weight-related load and bone mineral density (BMD)/bone microstructure under normal load conditions using high-resolution peripheral quantitative computed tomography (HR-pQCT) remains unconfirmed. The study aims to investigate the differences in effect of body mass index (BMI) on BMD/bone microstructure of loaded and unloaded bones, respectively, in Japanese postmenopausal women. Methods Fifty-seven postmenopausal women underwent HR-pQCT on the tibia and radius. Correlation analysis, principal component (PC) analysis, and hierarchical multiple regression were performed to examine the relationship between BMI and HR-pQCT parameters. Results Several microstructural parameters of the tibia and radius correlated with BMI through a simple correlation analysis, and these relationships remained unchanged even with an age-adjusted partial correlation analysis. PC analysis was conducted using seven bone microstructure parameters. The first PC (PC1) reflected all parameters of trabecular and cortical bone microstructures, except for cortical porosity, whereas the second PC (PC2) reflected only cortical bone microstructure. Hierarchical multiple regression analysis indicated that BMI was more strongly related to BMD/bone microstructure in the tibia than in the radius. Furthermore, BMI was associated with trabecular/cortical BMD, and PC1 (not PC2) of the tibia and radius. Thus, BMI was strongly related to the trabecular bone microstructure rather than the cortical bone microstructure. Conclusions Our data confirmed that BMI is associated with volumetric BMD and trabecular bone microstructure parameters in the tibia and radius. However, although BMI may be more related to HR-pQCT parameters in the tibia than in the radius, the magnitude of association is modest. |
Databáze: | OpenAIRE |
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