Ultrasonographic Evaluation of the Change in Uterine Fibroids Induced by Treatment with a Gnrh Analog
Autor: | Soon-Cen Huang, Hung-Jung Lee, Jye-Yi Kang, Kuo-Feng Huang, Chun-Chieh Chia, Shen-Shien Chen, Jing-Chuan Lin, Yuen-Shan Lin, Ching-Cheng Zheng |
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Rok vydání: | 2006 |
Předmět: |
Adult
medicine.medical_specialty Uterine fibroids Uterus Urology lcsh:Gynecology and obstetrics Drug Administration Schedule Gonadotropin-Releasing Hormone Imaging Three-Dimensional Vascularity Leuprorelin Obstetrics and Gynaecology medicine Humans Prospective Studies Pulse lcsh:RG1-991 Uterine leiomyoma Leiomyoma business.industry Obstetrics and Gynecology Ultrasonography Doppler uterine fibroid Blood flow Middle Aged medicine.disease female genital diseases and pregnancy complications Surgery GnRH analog Treatment Outcome medicine.anatomical_structure Regional Blood Flow Uterine Neoplasms Vascular resistance Blood Vessels Female Vascular Resistance medicine.symptom business medicine.drug |
Zdroj: | Taiwanese Journal of Obstetrics & Gynecology, Vol 45, Iss 2, Pp 124-128 (2006) |
ISSN: | 1028-4559 |
DOI: | 10.1016/s1028-4559(09)60209-6 |
Popis: | Summary Objective To investigate the change in volume of uterine fibroids after GnRH analog (GnRHa) treatment. Materials and Methods Twenty-five patients who had a uterine leiomyoma were included in this study. Four of them were lost to follow-up during the study, and a myomectomy was performed on the remaining subjects. All of these patients received two doses, 4 weeks apart, each of 3.75 mg leuprorelin acetate subcutaneously (Leuplin depot, a GnRHa) before the operation. The vascularization index (VI), flow index (FI), vascularization-flow index (VFI), pulsative index (PI), resistance index (RI), vascular patterns (histogram), blood flows, and sizes (volume and largest diameter) of each fibroid were measured with power Doppler by the same technician every month before the operation. In addition, the total blood loss and time required for each operation were also recorded. Results Results of this study showed that the volume of the uterus and the fibroids, but not the vascularity, including VI, FI, VFI, PI and RI, decreased significantly after two doses of GnRHa treatment. In addition, blood loss during the operation decreased significantly compared to an untreated group. Conclusion We found that the volumes of the uterus and fibroids decreased significantly after treatment with two consecutive doses (given a month apart) of GnRHa. The 3D color Doppler including a histogram and blood flow parameters is another useful tool for fibroid evaluation. |
Databáze: | OpenAIRE |
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