General Anesthesia Disrupts Complex Cortical Dynamics in Response to Intracranial Electrical Stimulation in Rats
| Autor: | Adenauer G. Casali, Johan F. Storm, Renzo Comolatti, Alessandro Arena, S. Thon |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Consciousness
media_common.quotation_subject Stimulation anesthesia Anesthesia General Electroencephalography Novel Tools and Methods 050105 experimental psychology Sevoflurane 03 medical and health sciences 0302 clinical medicine medicine Animals Humans rat General anaesthesia 0501 psychology and cognitive sciences Ketamine Wakefulness perturbational complexity index 030304 developmental biology media_common Coma 0303 health sciences OFF period medicine.diagnostic_test business.industry General Neuroscience 05 social sciences General Medicine Human brain Electric Stimulation Rats medicine.anatomical_structure connectivity Anesthesia medicine.symptom Propofol business Neuroscience Research Article: New Research 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | eneuro, Vol. 8, No. 4 eNeuro |
| ISSN: | 2373-2822 |
| Popis: | Visual Abstract The capacity of human brain to sustain complex cortical dynamics appears to be strongly associated with conscious experience and consistently drops when consciousness fades. For example, several recent studies in humans found a remarkable reduction of the spatiotemporal complexity of cortical responses to local stimulation during dreamless sleep, general anesthesia, and coma. However, this perturbational complexity has never been directly estimated in non-human animals in vivo previously, and the mechanisms that prevent neocortical neurons to engage in complex interactions are still unclear. Here, we quantify the complexity of electroencephalographic (EEG) responses to intracranial electrical stimulation in rats, comparing wakefulness to propofol, sevoflurane, and ketamine anesthesia. The evoked activity changed from highly complex in wakefulness to far simpler with propofol and sevoflurane. The reduced complexity was associated with a suppression of high frequencies that preceded a reduced phase-locking, and disruption of functional connectivity and pattern diversity. We then showed how these parameters dissociate with ketamine and depend on intensity and site of stimulation. Our results support the idea that brief periods of activity-dependent neuronal silence can interrupt complex interactions in neocortical circuits, and open the way for further mechanistic investigations of the neuronal basis for consciousness and loss of consciousness across species. |
| Databáze: | OpenAIRE |
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