Measuring tools for gastrointestinal toxicity
| Autor: | Ross N. Butler |
|---|---|
| Přispěvatelé: | Butler, Ross Norman |
| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Gastrointestinal Diseases noninvasive biomarkers medicine.medical_treatment Clinical Sciences Antineoplastic Agents Nursing Critical Care and Intensive Care Medicine Permeability medicine Mucositis Animals Humans Intensive care medicine Gastrointestinal Neoplasms Breath test Gastrointestinal tract Chemotherapy Radiotherapy medicine.diagnostic_test intestinal permeability Oncology (nursing) business.industry Cancer General Medicine medicine.disease Gastrointestinal Tract Radiation therapy Clinical trial intestinal function Breath Tests Oncology Public Health and Health Services Biomarker (medicine) business Biomarkers |
| Zdroj: | Current Opinion in Supportive and Palliative Care. 2:35-39 |
| ISSN: | 1751-4258 |
| DOI: | 10.1097/spc.0b013e3282f41b71 |
| Popis: | Purpose of review: The present review is timely owing to the previous paucity of biomarkers, particularly functional noninvasive tests, to evaluate the extent and severity of gastrointestinal toxicity in both animal models of chemotherapy and in cancer patients undergoing chemotherapy. Recent findings: The most recent findings using noninvasive functional biomarkers now allow longitudinal monitoring of the time course of damage and repair that occurs in the gastrointestinal tract following radiotherapy and chemotherapy. This monitoring has in turn enabled collection of objective evidence for efficacy of new antimucositis agents using animal models and, more importantly, for use in future randomized, double-blind, placebocontrolled clinical trials. Summary: In the past 12 months the 13C sucrose breath test has been applied to a series of animal models of chemotherapeutic damage, showing rapid monitoring of the efficacy of particular bioactive molecules is now possible at different stages of the damage and repair cycle. This biomarker has also been applied to childhood cancer studies of mucositis and now needs to be used in adult cancers for eventual adoption in routine clinical management of mucositis. An exciting possibility would be extension of the biomarker use to predict damage in other regions of the gastrointestinal tract, including oral mucosa. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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