Dose-related neurocognitive effects of marijuana use
Autor: | Jean Lud Cadet, Katrina Brown, Dana A. Eldreth, Karen I. Bolla, K. Tate |
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Rok vydání: | 2002 |
Předmět: |
Adult
Male Marijuana Abuse medicine.medical_specialty Adolescent Psychometrics media_common.quotation_subject Population Neuropsychological Tests Cognition Memory medicine Humans education Psychiatry media_common Psychomotor learning education.field_of_study Dose-Response Relationship Drug medicine.diagnostic_test biology Cognitive disorder Neuropsychological test Abstinence medicine.disease biology.organism_classification Female Neurology (clinical) Cannabis Cognition Disorders Psychology Neurocognitive Psychomotor Performance |
Zdroj: | Neurology. 59:1337-1343 |
ISSN: | 1526-632X 0028-3878 |
Popis: | Background: Although about 7 million people in the US population use marijuana at least weekly, there is a paucity of scientific data on persistent neurocognitive effects of marijuana use. Objective: To determine if neurocognitive deficits persist in 28-day abstinent heavy marijuana users and if these deficits are dose-related to the number of marijuana joints smoked per week. Methods: A battery of neurocognitive tests was given to 28-day abstinent heavy marijuana abusers. Results: As joints smoked per week increased, performance decreased on tests measuring memory, executive functioning, psychomotor speed, and manual dexterity. When dividing the group into light, middle, and heavy user groups, the heavy group performed significantly below the light group on 5 of 35 measures and the size of the effect ranged from 3.00 to 4.20 SD units. Duration of use had little effect on neurocognitive performance. Conclusions: Very heavy use of marijuana is associated with persistent decrements in neurocognitive performance even after 28 days of abstinence. It is unclear if these decrements will resolve with continued abstinence or become progressively worse with continued heavy marijuana use. |
Databáze: | OpenAIRE |
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