5-Methoxy-N,N-dimethyltryptamine: Spinal cord and brainstem mediation of excitatory effects on acoustic startle
| Autor: | David I. Astrachan, David S. Gendelman, Michael Davis, Phillip M. Gendelman |
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| Rok vydání: | 1980 |
| Předmět: |
Male
Reflex Startle Serotonin medicine.medical_specialty Methoxydimethyltryptamines Time Factors Phenoxybenzamine Dimethyltryptamine Stimulation Cyproheptadine Internal medicine medicine Animals 5-HT receptor Decerebrate State Pharmacology Dose-Response Relationship Drug Chemistry Rats Cinanserin Endocrinology Acoustic Stimulation Spinal Cord Acoustic Startle Reflex Brain Stem medicine.drug |
| Zdroj: | Psychopharmacology. 70:123-130 |
| ISSN: | 1432-2072 0033-3158 |
| Popis: | The effects of different doses (0.03, 0.06, 0.12, 0.25, 1.0, 2.0, 4.0, and 8.0 mg/kg body weight) of 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) were tested on the acoustic startle reflex in rats. Beginning at 0.12 mg/kg, 5-MeODMT increased startle monotonically up to the highest dose used. 5-MeODMT still increased startle in acutely decerebrate rats or when infused directly onto the spinal cord. The excitatory effects of a high systemic dose of 5-MeODMT were completely blocked by cinanserin, cyproheptadine, and propranolol, but not by parachlorophenylalanine, alpha-methyl-p-tyrosine, haloperidol, sotalol, or phenoxybenzamine. The results were discussed in terms of a new theory, which suggests that stimulation of serotonin receptors in the spinal cord enhance startle whereas serotonin receptors in the forebrain inhibit startle. |
| Databáze: | OpenAIRE |
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