Potential of Delayed Gadolinium Enhancement Magnetic Resonance Imaging for Quantification of Reverse Remodeling of the Peri-Infarct Zone in Patients With Ischemic Cardiomyopathy Treated With Chronic Vasodilator Therapy
| Autor: | David M. Naeger, Karen G. Ordovas, Giuseppe Cannavale, Stefano Muzzarelli, Charles B. Higgins, Andrew D. Michaels |
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| Přispěvatelé: | University of Zurich, Ordovas, Karen G |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine medicine.medical_specialty Vasodilator Agents Myocardial Infarction Contrast Media 610 Medicine & health Gadolinium Coronary Angiography Ventricular tachycardia 11171 Cardiocentro Ticino Article Statistics Nonparametric Electrocardiography Coronary circulation Coronary Circulation Internal medicine Image Interpretation Computer-Assisted 2741 Radiology Nuclear Medicine and Imaging Humans Medicine Radiology Nuclear Medicine and imaging cardiovascular diseases Myocardial infarction Ventricular remodeling delayed gadolinium enhancement magnetic resonance imaging myocardial infarction peri-infarct zone Aged Cardiomyopathies Dipyridamole Female Magnetic Resonance Imaging Middle Aged Retrospective Studies Tomography Emission-Computed Single-Photon Ventricular Remodeling Radiology Nuclear Medicine and Imaging Ischemic cardiomyopathy medicine.diagnostic_test business.industry Magnetic resonance imaging medicine.disease medicine.anatomical_structure 2740 Pulmonary and Respiratory Medicine cardiovascular system Cardiology business medicine.drug |
| Zdroj: | Muzzarelli, S; Ordovas, KG; Cannavale, G; Naeger, D; Michaels, AD; & Higgins, CB. (2012). Potential of delayed gadolinium enhancement magnetic resonance imaging for quantification of reverse remodeling of the peri-infarct zone in patients with ischemic cardiomyopathy treated with chronic vasodilator therapy: Initial experience. Journal of Thoracic Imaging, 27(2), 121-124. doi: 10.1097/RTI.0b013e3182125fb8. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/8m08n4dz |
| ISSN: | 0883-5993 |
| DOI: | 10.1097/rti.0b013e3182125fb8 |
| Popis: | Purpose: The peri-infarct zone represents the morphologic substrate for reentry ventricular tachycardia after myocardial infarction, and its extent is a strong predictor of major cardiac events. Although delayed gadolinium enhancement magnetic resonance imaging (DGE-MRI) was shown to allow for detailed characterization of myocardial infarction by quantifying infarct core zone and peri-infarct zone volume, potentials of DGE-MRI for measuring changes in peri-infarct zone volume are unknown. Therefore, we aimed to assess changes in volume of the peri-infarct zone among patients with ischemic cardiomyopathy treated with chronic vasodilator therapy. Materials and Methods: Core and peri-infarct zone volumes as assessed with DGE-MRI were measured in 5 patients at baseline and after 6 months treatment with sustained-release dipyridamole. Results: Core zone volume remained stable during follow-up [median (range), 19 mL (9 to 42) vs. 16 mL (11 to 46); P=0.785]. The ratio between the peri-infarct zone and the core zone volume decreased significantly at 6 months compared with baseline [median (range), 0.22 (0.19 to 0.42) vs. 0.18 (0.09 to 0.32); P=0.043], and a trend toward reduction in peri-infarct zone volume was found [median (range), 5 mL (2 to 8) vs. 3 mL (2 to 6); P=0.059]. The peri-infarct zone volume decreased in all but 1 patient over the follow-up. Conclusion: This initial experience suggests that reverse remodeling of the peri-infarct zone with reduction in peri-infarct zone volume may take place in patients with ischemic cardiomyopathy. Quantification of this process may be feasible with DGE-MRI, but further studies are needed to confirm this hypothesis and to further clarify the role of DGE-MRI for the assessment of changes in peri-infarct zone volume in patients with ischemic cardiomyopathy. Copyright © 2012 by Lippincott Williams & Wilkins. |
| Databáze: | OpenAIRE |
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