Increased Serum Levels of Macrophage Inflammatory Protein-3α and Cystatin A Predict a Poor Prognosis of Nasopharyngeal Carcinoma
| Autor: | Yong-Lin Cai, Wei Wang, Tang Minzhong, Weiming Zhong, Jun Li, Yuming Zheng, Hong Zeng, Ai-Ying Lu, Jianquan Gao |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Nasopharyngeal neoplasm Observational Study Gastroenterology Article Disease-Free Survival Young Adult Internal medicine Carcinoma Medicine Humans Cystatin A Prospective Studies Prospective cohort study Survival rate Macrophage inflammatory protein Survival analysis Aged Chemokine CCL20 Nasopharyngeal Carcinoma business.industry Nasopharyngeal Neoplasms General Medicine Middle Aged medicine.disease Prognosis Survival Rate Nasopharyngeal carcinoma Immunology Female business |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 0025-7974 |
| Popis: | This study was aimed to investigate the roles of serum macrophage inflammatory protein-3α (MIP-3α) and cystatin A in nasopharyngeal carcinoma (NPC) prognosis. The serum levels of MIP-3α and cystatin A in 140 primary NPC patients without distant metastasis were detected by enzyme-linked immunosorbent assay before and after treatment. The results were compared with those in 100 healthy controls. The log-rank test was used to compare survival curves of the 2 groups. Multivariate analysis of prognostic factors used Cox proportional hazards regression model. Serum levels of MIP-3α and cystatin A in pretreatment patients with NPC were higher than those in healthy controls. Concentrations of these 2 factors in the majority of patients after the therapy decreased to control level. Patients with high serum level of MIP-3α and cystatin A before treatment had poorer overall survival (OS), local recurrence-free survival, and distant metastasis-free survival than the ones with low level. In addition, serum pretreatment MIP-3α and cystatin A levels were independent prognostic factors for OS and distant metastasis-free survival of NPC patients; serum posttreatment MIP-3α and cystatin A levels were independent prognostic factors of local recurrence-free survival. Our results revealed that serum MIP-3α and cystatin A may be promising candidate prognostic factors for NPC, and higher serum levels of MIP-3α and cystatin A correlate with shorter probability of OS, local recurrence, and distant metastasis. |
| Databáze: | OpenAIRE |
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