An intramolecular antiparallel G-quadruplex formed by human telomere RNA
| Autor: | Tomokazu Shibata, Chao-Da Xiao, Yasuhiko Yamamoto, Yan Xu |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Circular dichroism Stereochemistry Antiparallel (biochemistry) G-quadruplex Catalysis 03 medical and health sciences Materials Chemistry Humans heterocyclic compounds Base sequence Base Sequence Chemistry Circular Dichroism Metals and Alloys Deoxyguanosine RNA General Chemistry Telomere Surfaces Coatings and Films Electronic Optical and Magnetic Materials G-Quadruplexes 030104 developmental biology Intramolecular force Ceramics and Composites |
| Zdroj: | Chemical Communications. 54:3944-3946 |
| ISSN: | 1364-548X 1359-7345 |
| DOI: | 10.1039/c8cc01427b |
| Popis: | Until now, RNA G-quadruplexes were believed to only adopt a parallel G-quadruplex structure. In this study, we describe the first observation of an antiparallel RNA G-quadruplex formed by human telomere RNA. This newly described topology is of great interest as it shows that RNA G-quadruplexes can also be polymorphic and adopt structures that are different from the parallel configuration. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|