A phytomodulatory hydrogel with enhanced healing effects
| Autor: | Mirele da Silveira Vasconcelos, José Vitor Lima-Filho, Felipe Domingos de Sousa, Ingrid Samantha Tavares de Figueiredo, Nylane M.N. Alencar, Emília Tomé de Sousa, Renato de Azevedo Moreira, Márcio V. Ramos, Tamiris de Fátima Goebel de Souza |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Latex Inflammation Pharmacology medicine.disease_cause complex mixtures Hydrogel Polyethylene Glycol Dimethacrylate Neovascularization Mice 03 medical and health sciences chemistry.chemical_compound Calotropis procera medicine Animals Wound Healing biology Plant Extracts technology industry and agriculture Malondialdehyde biology.organism_classification Epithelium Calotropis 030104 developmental biology medicine.anatomical_structure chemistry Myeloperoxidase biology.protein medicine.symptom Wound healing Oxidative stress |
| Zdroj: | Phytotherapy Research. 32:688-697 |
| ISSN: | 0951-418X |
| DOI: | 10.1002/ptr.6018 |
| Popis: | The healing performance of a hydrogel composed of hemicelluloses extracted from seeds of Caesalpinia pulcherrima (Fabaceae) and mixed with phytomodulatory proteins obtained from the latex of Calotropis procera was characterized on excisional wounds. The hydrogel did not induce dermal irritability. When topically used on excisional wounds, the hydrogel enhanced healing by wound contraction. Histology and the measurement of inflammatory mediators (myeloperoxidase, interleukin-1β, and interleukin-6) suggested that the inflammatory phase of the healing process was intensified, stimulating fibroplasia and neovascularization (proliferative phase) and tissue remodeling by increasing new collagen fiber deposition. In addition, reduction on levels of malondialdehyde in the groups that the hydrogel was applied suggested that the oxidative stress was reduced. The hydrogel performed better than the reference drug used, as revealed by the extended thickness of the remodeled epithelium. |
| Databáze: | OpenAIRE |
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