The correlation between morphology and implantation of euploid human blastocysts
| Autor: | Taraneh Gharib Nazem, Lucky Sekhon, Michael Whitehouse, Marlena Duke, Joseph A. Lee, Alan B. Copperman, Daniel E. Stein, Christine Briton-Jones, Stephanie Pan, Jessica Overbey |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
0301 basic medicine Pregnancy Rate Single Embryo Transfer Biology Andrology Young Adult 03 medical and health sciences 0302 clinical medicine Pregnancy medicine Humans Inner cell mass Embryo Implantation Blastocyst Retrospective Studies 030219 obstetrics & reproductive medicine Obstetrics and Gynecology Retrospective cohort study Embryo Middle Aged Embryo transfer Treatment Outcome 030104 developmental biology medicine.anatomical_structure Reproductive Medicine embryonic structures Female Ploidy Live birth Developmental Biology |
| Zdroj: | Reproductive BioMedicine Online. 38:169-176 |
| ISSN: | 1472-6483 |
| Popis: | Does the composite morphology score or a particular developmental component (expansion stage, inner cell mass [ICM] or trophectoderm [TE]) of euploid blastocysts undergoing single frozen embryo transfer (FET) impact ongoing pregnancy/live birth (OP/LB) rates?Retrospective cohort study including a total of 2236 embryos from 1629 patients who underwent single euploid FET between 2012 and 2017.Embryos with an ICM grade of A compared with C had a higher OP/LB rate (55.6% versus 32.3%, P 0.001). Blastocysts with a TE grade of A or B compared with C had a higher likelihood of OP/LB (A versus C: odds ratio [OR] 1.6, 99% confidence interval [CI] 1.1-2.3, B versus C: OR 1.5, 99% CI 1.1-2.1), and blastocysts with a developmental stage of 4 or 5 compared with 6 had higher odds of OP/LB (4 versus 6: OR 1.6, 99% CI 1.2-2.2, 5 versus 6: OR 1.6, 99% CI 1.2-2.3).Among euploid embryos, ICM morphology is the best predictor of sustained implantation; however, a composite score may provide additional guidance. While there is a known benefit in genomic screening prior to embryo selection, morphology provides individualized, prognostic information about implantation potential. |
| Databáze: | OpenAIRE |
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