Pharmacokinetics of piperacillin during pregnancy
| Autor: | A Heikkilä, R. Erkkola |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Microbiology (medical) Amniotic fluid medicine.medical_treatment Pharmacokinetics Pregnancy medicine.artery medicine Humans Distribution (pharmacology) Pharmacology (medical) Caesarean section Maternal-Fetal Exchange reproductive and urinary physiology Piperacillin Pharmacology business.industry Umbilical artery medicine.disease Infectious Diseases Anesthesia Gestation Female business Half-Life medicine.drug |
| Zdroj: | Journal of Antimicrobial Chemotherapy. 28:419-423 |
| ISSN: | 1460-2091 0305-7453 |
| DOI: | 10.1093/jac/28.3.419 |
| Popis: | The pharmacokinetics of piperacillin during pregnancy were investigated. Eight pregnant women received 4 g of piperacillin intravenously before caesarean section. Likewise, five non-pregnant subjects of child bearing age received the same dose before a gynaecological operation. The mean peak plasma concentrations of piperacillin were 87.5 and 172.2 mg/L for the pregnant and non-pregnant patients, respectively. The mean umbilical vein concentration was 9.7 mg/L; the mean umbilical artery concentration was 7.4 mg/L and the amniotic fluid concentration 6.8 mg/L. The feto-maternal ratio at the time of caesarean section was 0.27. Pharmacokinetic parameters of piperacillin indicate larger volumes of distribution and higher clearance rates during pregnancy compared with the non-pregnant state. The altered pharmacokinetics of piperacillin during pregnancy suggest that higher doses may be required for effective treatment of serious infections in pregnant women near term. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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