Angiotensin-II Receptor Blocker Exerts Cardioprotection in Diabetic Rats Exposed to Hypoxia
| Autor: | Naoko Tazawa, Daisuke Nakano, Koichi Sohmiya, Tetsuya Hayashi, Chika Yamashita, Eisuke Furuya, Tatsuhiko Mori, Nobuaki Okuda, Akiko Sakai, Sakiko Inamoto, Yasushi Kitaura, Yasuo Matsumura |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Vascular Endothelial Growth Factor A medicine.medical_specialty Angiotensin receptor Heart Diseases Drug Evaluation Preclinical Tetrazoles Blood Pressure Diabetes Mellitus Experimental chemistry.chemical_compound Sleep Apnea Syndromes Internal medicine medicine Animals Humans Ventricular Function Myocytes Cardiac Hypoxia Ventricular remodeling Metabolic Syndrome Cardioprotection business.industry Myocardium Biphenyl Compounds Sleep apnea General Medicine Hypoxia (medical) Hypoxia-Inducible Factor 1 alpha Subunit medicine.disease Rats Vascular endothelial growth factor Candesartan Endocrinology Blood pressure Gene Expression Regulation chemistry Benzimidazoles medicine.symptom Cardiology and Cardiovascular Medicine business Angiotensin II Type 1 Receptor Blockers medicine.drug |
| Zdroj: | Circulation Journal. 70:787-792 |
| ISSN: | 1347-4820 1346-9843 |
| Popis: | BACKGROUND Hypoxia caused by sleep apnea might be associated with an increased risk of cardiovascular events in subjects with metabolic syndrome. The aim of this study was to examine the effect of hypoxia on the left ventricular (LV) myocardium and evaluate the cardioprotective effect of an angiotensin-II receptor blocker (ARB) in diabetic rats. METHODS AND RESULTS Male Otsuka Long-Evans Tokushima Fatty (OLETF) rats at 30 weeks of age (n=30) were divided into 2 groups that were treated with vehicle or candesartan 0.2 mg x kg(-1) x day (-1). The animals were housed in a hypoxic gas chamber (oxygen, 10.0+/-0.5%, mean +/- standard deviation) for 2 weeks. Hypoxia increased right ventricular (RV) systolic pressure (hypoxia; 78+/-14 mmHg vs control; 22+/-5, p |
| Databáze: | OpenAIRE |
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