Copaiba oil-resin (Copaifera reticulata Ducke) modulates the inflammation in a model of injury to rats’ tongues
Autor: | Roberta Souza D'Almeida Couto, Francisco Bruno Teixeira, Manoela Domingues Martins, Rafael Rodrigues Lima, Osmar Alves Lameira, Liana Preto Webber, Raíra de Brito Silva |
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Přispěvatelé: | Francisco Bruno Teixeira, UFPA, Raíra de Brito Silva, UFPA, OSMAR ALVES LAMEIRA, CPATU, Liana Preto Webber, UFRGS, Roberta Souza D'Almeida Couto, UFPA, Manoela Domingues Martins, UFRGS, Rafael Rodrigues Lima, UFPA. |
Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
Male
0301 basic medicine Model of injury Pathology Fitoterapia Macrophage Anti-Inflammatory Agents Pharmacology Copaiba Oil Tongue Diseases 0302 clinical medicine Medicine Tissue homeostasis biology Fabaceae General Medicine lcsh:Other systems of medicine Copaíba 030220 oncology & carcinogenesis Inflamacoes medicine.symptom Research Article medicine.medical_specialty Copaifera Reticulata Ducke Copaifera Inflammation Amazonian biodiversity 03 medical and health sciences Copaiba Animals Humans Plant Oils Rats Wistar Wound Healing Plant Extracts business.industry Copaiba oil-resin biology.organism_classification lcsh:RZ201-999 Acute toxicity Complementary therapies Rats Planta Medicinal 030104 developmental biology Complementary and alternative medicine Patologia bucal Chronic Inflammatory Infiltrate business Wound healing Resins Plant |
Zdroj: | BMC Complementary and Alternative Medicine, Vol 17, Iss 1, Pp 1-8 (2017) Repositório Institucional da UFRGS Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA-Alice) Empresa Brasileira de Pesquisa Agropecuária (Embrapa) instacron:EMBRAPA BMC Complementary and Alternative Medicine |
ISSN: | 1472-6882 |
Popis: | Background The regeneration of integrity and tissue homeostasis after injury is a fundamental property and involves complex biological processes fully dynamic and interconnected. Although there are medications prescribed to accelerate the process of wound healing by reducing the exaggerated inflammatory response, comes the need to search for different compounds of Amazonian biodiversity that can contribute to the acceleration of the healing process. Among these products, the copaiba oil-resin is one of the most prominent feature in this scenario, as they have been reported its medicinal properties. Methods Aiming to evaluate the anti-inflammatory and healing effect of copaiba oil-resin (Copaifera reticulata Ducke) in transfixing injury of rats’ tongues first proceeded up the copaiba oil-resin oral toxicity test in 5 male mice to stipulate the therapeutic dose which was established at 200 mg/kg/day. Then it was induced transfixing injury in a total of 15 Wistar rats. The animals were randomly divided into three groups based on the treatment: control group, dexamethasone group and copaiba oil-resin group. After 7 days of treatment, histological slides stained with hematoxylin and eosin was prepared. Immunohistochemistry for CD68 (macrophage marker) was performed and analyzed by the cell counter Image J. Results The acute toxicity test showed that the oil-resin copal has low toxicity. Furthermore, copaiba oil-resin therapy modulates the inflammatory response by decreasing the chronic inflammatory infiltrate, edema and specifically the number of macrophages. Conclusions The results indicate the potential of the Amazon region and showed up relevant because therapy with this extract modulates the inflammatory process. |
Databáze: | OpenAIRE |
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