Copaiba oil-resin (Copaifera reticulata Ducke) modulates the inflammation in a model of injury to rats’ tongues

Autor: Roberta Souza D'Almeida Couto, Francisco Bruno Teixeira, Manoela Domingues Martins, Rafael Rodrigues Lima, Osmar Alves Lameira, Liana Preto Webber, Raíra de Brito Silva
Přispěvatelé: Francisco Bruno Teixeira, UFPA, Raíra de Brito Silva, UFPA, OSMAR ALVES LAMEIRA, CPATU, Liana Preto Webber, UFRGS, Roberta Souza D'Almeida Couto, UFPA, Manoela Domingues Martins, UFRGS, Rafael Rodrigues Lima, UFPA.
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Male
0301 basic medicine
Model of injury
Pathology
Fitoterapia
Macrophage
Anti-Inflammatory Agents
Pharmacology
Copaiba Oil
Tongue Diseases
0302 clinical medicine
Medicine
Tissue homeostasis
biology
Fabaceae
General Medicine
lcsh:Other systems of medicine
Copaíba
030220 oncology & carcinogenesis
Inflamacoes
medicine.symptom
Research Article
medicine.medical_specialty
Copaifera Reticulata Ducke
Copaifera
Inflammation
Amazonian biodiversity
03 medical and health sciences
Copaiba
Animals
Humans
Plant Oils
Rats
Wistar
Wound Healing
Plant Extracts
business.industry
Copaiba oil-resin
biology.organism_classification
lcsh:RZ201-999
Acute toxicity
Complementary therapies
Rats
Planta Medicinal
030104 developmental biology
Complementary and alternative medicine
Patologia bucal
Chronic Inflammatory Infiltrate
business
Wound healing
Resins
Plant
Zdroj: BMC Complementary and Alternative Medicine, Vol 17, Iss 1, Pp 1-8 (2017)
Repositório Institucional da UFRGS
Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA-Alice)
Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
instacron:EMBRAPA
BMC Complementary and Alternative Medicine
ISSN: 1472-6882
Popis: Background The regeneration of integrity and tissue homeostasis after injury is a fundamental property and involves complex biological processes fully dynamic and interconnected. Although there are medications prescribed to accelerate the process of wound healing by reducing the exaggerated inflammatory response, comes the need to search for different compounds of Amazonian biodiversity that can contribute to the acceleration of the healing process. Among these products, the copaiba oil-resin is one of the most prominent feature in this scenario, as they have been reported its medicinal properties. Methods Aiming to evaluate the anti-inflammatory and healing effect of copaiba oil-resin (Copaifera reticulata Ducke) in transfixing injury of rats’ tongues first proceeded up the copaiba oil-resin oral toxicity test in 5 male mice to stipulate the therapeutic dose which was established at 200 mg/kg/day. Then it was induced transfixing injury in a total of 15 Wistar rats. The animals were randomly divided into three groups based on the treatment: control group, dexamethasone group and copaiba oil-resin group. After 7 days of treatment, histological slides stained with hematoxylin and eosin was prepared. Immunohistochemistry for CD68 (macrophage marker) was performed and analyzed by the cell counter Image J. Results The acute toxicity test showed that the oil-resin copal has low toxicity. Furthermore, copaiba oil-resin therapy modulates the inflammatory response by decreasing the chronic inflammatory infiltrate, edema and specifically the number of macrophages. Conclusions The results indicate the potential of the Amazon region and showed up relevant because therapy with this extract modulates the inflammatory process.
Databáze: OpenAIRE
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