Cerebral vasomotor reactivity across the continuum of subjective cognitive impairment, amnestic mild cognitive impairment and probable Alzheimer's dementia: A transcranial Doppler and PET/MRI study

Autor:	Esen Saka, Lutfiye Ozlem Atay, Umit Ozgur Akdemir, Ezgi Yetim, Erdem Balci, Ethem Murat Arsava, Mehmet Akif Topcuoglu
Rok vydání:	2022
Předmět:	Neurology Alzheimer Disease Humans Female Cognitive Dysfunction Neurology (clinical) Middle Aged Cardiology and Cardiovascular Medicine
Zdroj:	Journal of Cerebral Blood Flow & Metabolism. 43:129-137
ISSN:	1559-7016 0271-678X
DOI:	10.1177/0271678x221124656
Popis:	Cerebrovascular dysfunction has been suggested as a physiomarker of Alzheimer's disease (AD)-associated neuronal degeneration, but the underlying mechanisms are still debated. Herein cerebral vasomotor reactivity (VMR, breath-hold index: BHI), metabolic activity (lobar SUVs, FDG PET MRI), amyloid load (Centiloid score, Flutemetamol PET MRI), hemispheric cortical thickness, white matter lesion load and cerebral blood flow (ASL) were studied in 43 consecutive subjects (mean age: 64 years, female 13), diagnosed with subjective cognitive impairment (SCI, n = 10), amnestic mild cognitive impairment (aMCI, n = 15), and probable Alzheimer's dementia (AD, n = 18). BHI was significantly reduced in AD and aMCI patients compared to SCI subjects. A highly significant inverse correlation was found between BHI and the centiloid score (r = −0.648, p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1593e0b98fcd0fb7f22fb24b5c6f6529 https://doi.org/10.1177/0271678x221124656 Zobrazit plný text záznamu