R2d2 drives selfish sweeps in the house mouse
| Autor: | George M. Weinstock, Amanda J. Chunco, Lydia Ortiz de Solorzano, Meng-Shin Shiao, Sofia I. Gabriel, Daniel Pomp, David W. Threadgill, Riccardo Castiglia, Mabel D. Giménez, Stephan P. Rosshart, Wesley J. Jolley, John P. Didion, Heidi C. Hauffe, Fernando Pardo-Manuel de Villena, John E. French, Jeremy B. Searle, İslam Gündüz, Eva B. Giagia-Athanasopoulou, Emanuela Solano, Yung-Hao Ching, Kunji Hua, María J López-Fuster, Janice Britton-Davidian, Karen L. Svenson, Theodore Garland, Carol J. Bult, M Graça Ramalhinho, Andrew P. Morgan, Anna K. Lindholm, James J. Crowley, James Holt, Liran Yadgary, Barbara Rehermann, Pat Thomas-Laemont, Gary A. Churchill, Timothy A. Bell, Karl J. Campbell, Jacint Ventura Queija, Leonard McMillan, Daniel M. Gatti, Maria da Luz Mathias, George P. Mitsainas, Sofia A. Grize, Andrew Holmes, Rachel C. McMullan, Elissa J. Chesler, Jeremy S. Herman |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
0106 biological sciences
0303 health sciences education.field_of_study Selfish Genes Population Biology 010603 evolutionary biology 01 natural sciences 03 medical and health sciences Fixation (population genetics) Meiotic drive Genetic drift Evolutionary biology Darwinian Fitness Allele education Selective sweep 030304 developmental biology |
| DOI: | 10.1101/024851 |
| Popis: | A selective sweep is the result of strong positive selection rapidly driving newly occurring or standing genetic variants to fixation, and can dramatically alter the pattern and distribution of allelic diversity in a population or species. Population-level sequencing data have enabled discoveries of selective sweeps associated with genes involved in recent adaptations in many species. In contrast, much debate but little empirical evidence addresses whether "selfish" genes are capable of fixation -- thereby leaving signatures identical to classical selective sweeps -- despite being neutral or deleterious to organismal fitness. We previously reported the discovery of R2d2, a large copy-number variant that causes non-random segregation of mouse Chromosome 2 in females due to meiotic drive. Here we show population-genetic data consistent with a "selfish" sweep driven by alleles of R2d2 with high copy number (R2d2HC) in natural populations of mice. We replicate this finding in multiple closed breeding populations from six outbred backgrounds segregating for R2d2 alleles. We find that R2d2HC rapidly increases in frequency, and in most cases becomes fixed in significantly fewer generations than can be explained by genetic drift. R2d2HC is also associated with significantly reduced litter sizes in heterozygosity, making it a true selfish allele. Our data provide direct evidence of populations actively undergoing selfish sweeps, and demonstrate that meiotic drive can rapidly alter the genomic landscape in favor of mutations with neutral or even negative effects on overall Darwinian fitness. Further study will reveal the incidence of selfish sweeps, and will elucidate the relative contributions of selfish genes, adaptation and genetic drift to evolution. |
| Databáze: | OpenAIRE |
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