Review: Angiotensin Peptides and their Pleiotropic Actions
| Autor: | Dragomir N. Serban, Walther Bild, I. Haulica |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
0301 basic medicine
Medicine (General) medicine.medical_specialty Angiotensin receptor Angiotensin II receptor type 1 Biological activity 030204 cardiovascular system & hematology Biology Angiotensin II Cell biology 03 medical and health sciences Paracrine signalling R5-920 030104 developmental biology 0302 clinical medicine Endocrinology Internal medicine Renin–angiotensin system Internal Medicine medicine Autocrine signalling Receptor hormones hormone substitutes and hormone antagonists |
| Zdroj: | Journal of the Renin-Angiotensin-Aldosterone System, Vol 6 (2005) |
| ISSN: | 1752-8976 1470-3203 |
| Popis: | The concept of tissue renin-angiotensin systems (RAS) is now well established and it is now usual to think in terms of renal and tissue systems. At the same time it has emerged that angiotensin II (Ang II) is not the only biologically active peptide generated by the RAS. At least three others have been identified: the heptapeptide Ang III, the hexapeptide Ang IV and Ang 1-7. Specific receptors exits for the last two peptides. In addition, the range of possible physiological and pathophysiological properties for Ang II„ has been expanding. The current perception of the RAS is therefore that of a much more complex system than previously believed, with autocrine, paracrine and endocrine properties extending beyond the cardiovascular system. This mini-review focuses on the synthetic pathways of the Ang peptides and describes some of their pleiotropic actions. |
| Databáze: | OpenAIRE |
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