Evaluation of the usefulness of saliva for mosaic loss of chromosome Y analysis

Autor:	Takuro Kobayashi, Tsuyoshi Hachiya, Wataru Tsutae, Pamela Hui Peng Gan, Iri Sato Baran, Shigeo Horie
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Adult Male Saliva Aging Science Increased physical activity Biology Article Cigarette Smoking fluids and secretions Japan stomatognathic system Leukocytes Humans Exercise Aged Genetic association study Aged 80 and over Multidisciplinary Chromosomes Human Y Mosaicism Chromosome Middle Aged stomatognathic diseases Immunology Biomarker (medicine) Medicine Chromosome Deletion Biomarkers
Zdroj:	Scientific Reports, Vol 11, Iss 1, Pp 1-6 (2021) Scientific Reports
ISSN:	2045-2322
Popis:	Mosaic loss of chromosome Y (mLOY) in leukocytes has attracted much attention as an emerging biomarker of aging and aging-related diseases. We evaluated the usefulness of saliva for mLOY analysis and showed that saliva-derived mLOY is significantly associated with aging and increased physical activity, but not with smoking. While these data support the robust association between saliva-derived mLOY and aging, caution is required when comparing data from saliva-derived and blood-derived mLOY.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1591a971c200ad04cb4bf41f97ba5e1d https://doaj.org/article/5f696ba12a9547d09eeb108bedab312c Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.