An Exploratory Analysis of Tamsulosin for Overactive Bladder (OAB) in Men With Varying Voiding Symptom Burden
| Autor: | Theodore M. Johnson, Kathryn L. Burgio, Patricia S. Goode, Lee N. Hammontree, Joseph G. Ouslander, Kerac N Falk, Camille P. Vaughan, Gerald McGwin, Alayne D. Markland |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Tamsulosin medicine.medical_specialty Urinary urgency Urology Urinary system Prostatic Hyperplasia 030232 urology & nephrology urologic and male genital diseases 03 medical and health sciences 0302 clinical medicine Cost of Illness Humans Medicine Prospective Studies Aged Aged 80 and over Urinary Bladder Overactive business.industry Symptom burden Exploratory analysis Middle Aged medicine.disease humanities female genital diseases and pregnancy complications Treatment Outcome Overactive bladder Symptom improvement 030220 oncology & carcinogenesis Concomitant Adrenergic alpha-1 Receptor Antagonists Symptom Assessment medicine.symptom business medicine.drug |
| Zdroj: | Urology. 153:42-48 |
| ISSN: | 0090-4295 |
| Popis: | To evaluate tamsulosin (α-blocker therapy) for male overactive bladder (OAB) and to examine if indicators of concomitant benign prostatic hyperplasia are associated with OAB symptom improvement.This was a planned, exploratory analysis of a 4-week, α-blocker (tamsulosin 0.4 mg) run-in phase of the Male Overactive Bladder Trial in Veterans (MOTIVE). Participants with urinary urgency and urinary frequency (8 voids/24 hours) completed bladder diaries, answered symptom questionnaires (AUA-7 SI), and had post-void residual and noninvasive uroflowmetry measurement.A total of 116 male Veterans aged 42-88 years with OAB participated. There were statistically significant reductions in voiding frequency (11.310.0 voids/24 hours, P.0001), urgency scores (mean 2.5-2.2 points, P.0001), and nightly nocturia (2.11.8, P.001). Only baseline AUA-7 SI total and voiding subscale categories (mild, moderate, severe) were associated with significant reduction in AUA-7 SI total score. For continuous variables, only AUA-7 SI baseline total score was associated with AUA-7 SI storage symptom changes. No other baseline measures were associated with changes in urgency, frequency, or nocturia.Initiation of short course tamsulosin therapy in men was associated with statistical reduction in OAB symptoms. Baseline post-void residual, uroflow rate, and the voiding symptom subscore of the AUA-7 SI were not predictive of OAB symptom improvement with tamsulosin. These findings merits further exploration. |
| Databáze: | OpenAIRE |
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